7 variants found for MT-ND1 p.M1L

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MT-ND1 · c.1A>C (p.Met1Leu) protein-coding
Genome location
D-loop · dloop · 16024–16569D-loop · dloop · 1–576MT-TF · tRNA · 577–647MT-RNR1 · rRNA · 648–1601MT-TV · tRNA · 1602–1670MT-RNR2 · rRNA · 1671–3229MT-TL1 · tRNA · 3230–3304MT-ND1 · protein · 3307–4262MT-TI · tRNA · 4263–4331MT-TQ · tRNA · 4329–4400MT-TM · tRNA · 4402–4469MT-ND2 · protein · 4470–5511MT-TW · tRNA · 5512–5579MT-TA · tRNA · 5587–5655MT-TN · tRNA · 5657–5729MT-TC · tRNA · 5761–5826MT-TY · tRNA · 5826–5891MT-CO1 · protein · 5904–7445MT-TS1 · tRNA · 7446–7514MT-TD · tRNA · 7518–7585MT-CO2 · protein · 7586–8269MT-TK · tRNA · 8295–8364MT-ATP8 · protein · 8366–8572MT-ATP6 · protein · 8527–9207MT-CO3 · protein · 9207–9990MT-TG · tRNA · 9991–10058MT-ND3 · protein · 10059–10404MT-TR · tRNA · 10405–10469MT-ND4L · protein · 10470–10766MT-ND4 · protein · 10760–12137MT-TH · tRNA · 12138–12206MT-TS2 · tRNA · 12207–12265MT-TL2 · tRNA · 12266–12336MT-ND5 · protein · 12337–14148MT-ND6 · protein · 14149–14673MT-TE · tRNA · 14674–14742MT-CYB · protein · 14747–15887MT-TT · tRNA · 15888–15953MT-TP · tRNA · 15956–16023MT-ND1m.3307A>C
MT-ND1 · protein-coding
protein tRNA rRNA D-loop
3D structure: where is this variant?
highlighted: residue 1 of MT-ND1 · drag to rotate, scroll to zoom.
General information
Variant ID MITHRIL.9919
MitImpact ID MI.10755
Chromosome chrM
Position 3307
Alleles (Ref/Alt) A/C
Molecule type protein-coding
Gene MT-ND1
Gene description mitochondrially encoded NADH:ubiquinone oxidoreductase core subunit 1
Gene (start-end) 3307-4262
Position within gene 1
Strand +
HGVS NC_012920.1:m.3307A>C
Functional effect Start lost
Respiratory chain complex I
External identifiers
Ensembl gene ENSG00000198888
Ensembl transcript ENST00000361390
Ensembl protein ENSP00000354687
UniProt NU1M_HUMAN (P03886)
NCBI gene 4535
NCBI protein YP_003024026.1
OMIM 516000
HGNC HGNC:7455
MITOMAP allele 3307A>C
Phylogenetic conservation
PhyloP (100V) 3.333
PhastCons (100V) 0.981
PhyloP (470-way) 0.58
PhastCons (470-way) 0.225
Amino-acid change
Codon substitution ATA/CTA
Reference AA M
Alternate AA L
AA position 1
Pathogenicity predictors
PolyPhen-2 Probably damaging
SIFT Deleterious
SIFT4G Neutral
PROVEAN Neutral
MutationTaster Disease causing
EFIN (SwissProt) Neutral
EFIN (HumDiv) Deleterious
LIST-S2 Deleterious
ESM1b Neutral
SNPDryad Neutral
Mitoclass1 Neutral
CADD Neutral
VEST Neutral
MLC Deleterious
Meta-predictors
APOGEE1 Deleterious
APOGEE2 VUS-
CAROL Deleterious
Condel Neutral
COVEC WMV Deleterious
MToolBox Deleterious
DEOGEN2 Neutral
Cancer-specific predictors
CHASM Neutral
Allele frequencies
MITOMAP known variant True
MITOMAP GenBank freq (seqs) 0 (0)
HelixMTdb hom AF (AC) 0 (1)
HelixMTdb het AF (AC) 0 (0)
ToMMo 61KJPN AF (AC) 0 (2)
ToMMo 61KJPN AN 61424
Residue interaction & stability
ΔΔG intra MT-ND1:M1L:I166F:1.36476:0.192435:1.16217;MT-ND1:M1L:I166V:0.661174:0.192435:0.715933;MT-ND1:M1L:I166M:-0.418223:0.192435:-0.594445;MT-ND1:M1L:I166T:0.84114:0.192435:0.604375;MT-ND1:M1L:I166S:0.937385:0.192435:0.970766;MT-ND1:M1L:I166L:-0.179628:0.192435:-0.420996;MT-ND1:M1L:I166N:1.93474:0.192435:1.63769;MT-ND1:M1L:A201G:0.862901:0.192435:0.725;MT-ND1:M1L:A201P:-0.656027:0.192435:-0.598678;MT-ND1:M1L:A201V:2.62898:0.192435:2.44106;MT-ND1:M1L:A201T:3.40554:0.192435:3.20878;MT-ND1:M1L:A201D:4.71536:0.192435:4.42968;MT-ND1:M1L:A201S:0.474202:0.192435:0.373424;MT-ND1:M1L:A249V:0.617033:0.192435:0.387706;MT-ND1:M1L:A249P:-0.77212:0.192435:-0.969457;MT-ND1:M1L:A249E:0.257047:0.192435:-0.081467;MT-ND1:M1L:A249G:0.477486:0.192435:0.24999;MT-ND1:M1L:A249T:0.779175:0.192435:0.585672;MT-ND1:M1L:A249S:0.635345:0.192435:0.416877;MT-ND1:M1L:P2R:0.900436:0.192435:0.63914;MT-ND1:M1L:P2H:1.04822:0.192435:0.926272;MT-ND1:M1L:P2L:0.33879:0.192435:0.109703;MT-ND1:M1L:P2T:0.36449:0.192435:0.178692;MT-ND1:M1L:P2A:0.613412:0.192435:0.449523;MT-ND1:M1L:P2S:0.21351:0.192435:0.119094;MT-ND1:M1L:M3V:1.05132:0.192435:0.898191;MT-ND1:M1L:M3T:1.55474:0.192435:1.3373;MT-ND1:M1L:M3I:0.527411:0.192435:0.24161;MT-ND1:M1L:M3K:0.720049:0.192435:0.647219;MT-ND1:M1L:M3L:0.255773:0.192435:0.320405
ΔΔG intra-interface MT-ND1:NDUFA1:5lc5:H:a:M1L:A249E:1.38641:1.35322:0.01115;MT-ND1:NDUFA1:5lc5:H:a:M1L:A249G:1.44097:1.35322:-0.0572;MT-ND1:NDUFA1:5lc5:H:a:M1L:A249P:1.51825:1.35322:-0.00503;MT-ND1:NDUFA1:5lc5:H:a:M1L:A249S:1.2709:1.35322:-0.08213;MT-ND1:NDUFA1:5lc5:H:a:M1L:A249T:1.6929:1.35322:0.19588;MT-ND1:NDUFA1:5lc5:H:a:M1L:A249V:1.3148:1.35322:0.16957;MT-ND1:NDUFA1:5ldw:H:a:M1L:A249E:0.67155:0.9567:0.02682;MT-ND1:NDUFA1:5ldw:H:a:M1L:A249G:1.14673:0.9567:0.38432;MT-ND1:NDUFA1:5ldw:H:a:M1L:A249P:0.56007:0.9567:-0.0544;MT-ND1:NDUFA1:5ldw:H:a:M1L:A249S:0.17561:0.9567:-0.69158;MT-ND1:NDUFA1:5ldw:H:a:M1L:A249T:0.80157:0.9567:0.24228;MT-ND1:NDUFA1:5ldw:H:a:M1L:A249V:1.14937:0.9567:0.18985
Intra-protein co-variation
1 ↔ 4: 32.9132 (mfDCA)1 ↔ 175: 30.1899 (mfDCA)1 ↔ 2: 29.9569 (mfDCA)1 ↔ 239: 27.6626 (mfDCA)1 ↔ 239: 27.6626 (mfDCA)1 ↔ 263: 27.31 (mfDCA)1 ↔ 9: 26.4013 (cMI)1 ↔ 300: 23.2395 (mfDCA)1 ↔ 3: 23.1959 (mfDCA)1 ↔ 3: 23.1959 (mfDCA)1 ↔ 166: 22.8794 (mfDCA)1 ↔ 166: 22.8794 (mfDCA)1 ↔ 5: 20.0005 (cMI)1 ↔ 201: 18.6094 (mfDCA)1 ↔ 10: 17.4958 (cMI)1 ↔ 14: 17.3247 (cMI)1 ↔ 249: 14.8015 (mfDCA)1 ↔ 12: 13.6194 (cMI)1 ↔ 4: 32.9132 (mfDCA)432.91321 ↔ 175: 30.1899 (mfDCA)17530.18991 ↔ 2: 29.9569 (mfDCA)229.95691 ↔ 239: 27.6626 (mfDCA)23927.66261 ↔ 239: 27.6626 (mfDCA)23927.66261 ↔ 263: 27.31 (mfDCA)26327.311 ↔ 9: 26.4013 (cMI)926.40131 ↔ 300: 23.2395 (mfDCA)30023.23951 ↔ 3: 23.1959 (mfDCA)323.19591 ↔ 3: 23.1959 (mfDCA)323.19591 ↔ 166: 22.8794 (mfDCA)16622.87941 ↔ 166: 22.8794 (mfDCA)16622.87941 ↔ 5: 20.0005 (cMI)520.00051 ↔ 201: 18.6094 (mfDCA)20118.60941 ↔ 10: 17.4958 (cMI)1017.49581 ↔ 14: 17.3247 (cMI)1417.32471 ↔ 249: 14.8015 (mfDCA)24914.80151 ↔ 12: 13.6194 (cMI)1213.619411

Same protein (MT-ND1); edge ∝ covariation score.

Show all 18 as text
  • 4: 32.9132 (mfDCA)
  • 175: 30.1899 (mfDCA)
  • 2: 29.9569 (mfDCA)
  • 239: 27.6626 (mfDCA)
  • 239: 27.6626 (mfDCA)
  • 263: 27.31 (mfDCA)
  • 9: 26.4013 (cMI)
  • 300: 23.2395 (mfDCA)
  • 3: 23.1959 (mfDCA)
  • 3: 23.1959 (mfDCA)
  • 166: 22.8794 (mfDCA)
  • 166: 22.8794 (mfDCA)
  • 5: 20.0005 (cMI)
  • 201: 18.6094 (mfDCA)
  • 10: 17.4958 (cMI)
  • 14: 17.3247 (cMI)
  • 249: 14.8015 (mfDCA)
  • 12: 13.6194 (cMI)
MT-ND1 · c.1A>T (p.Met1Leu) protein-coding
Genome location
D-loop · dloop · 16024–16569D-loop · dloop · 1–576MT-TF · tRNA · 577–647MT-RNR1 · rRNA · 648–1601MT-TV · tRNA · 1602–1670MT-RNR2 · rRNA · 1671–3229MT-TL1 · tRNA · 3230–3304MT-ND1 · protein · 3307–4262MT-TI · tRNA · 4263–4331MT-TQ · tRNA · 4329–4400MT-TM · tRNA · 4402–4469MT-ND2 · protein · 4470–5511MT-TW · tRNA · 5512–5579MT-TA · tRNA · 5587–5655MT-TN · tRNA · 5657–5729MT-TC · tRNA · 5761–5826MT-TY · tRNA · 5826–5891MT-CO1 · protein · 5904–7445MT-TS1 · tRNA · 7446–7514MT-TD · tRNA · 7518–7585MT-CO2 · protein · 7586–8269MT-TK · tRNA · 8295–8364MT-ATP8 · protein · 8366–8572MT-ATP6 · protein · 8527–9207MT-CO3 · protein · 9207–9990MT-TG · tRNA · 9991–10058MT-ND3 · protein · 10059–10404MT-TR · tRNA · 10405–10469MT-ND4L · protein · 10470–10766MT-ND4 · protein · 10760–12137MT-TH · tRNA · 12138–12206MT-TS2 · tRNA · 12207–12265MT-TL2 · tRNA · 12266–12336MT-ND5 · protein · 12337–14148MT-ND6 · protein · 14149–14673MT-TE · tRNA · 14674–14742MT-CYB · protein · 14747–15887MT-TT · tRNA · 15888–15953MT-TP · tRNA · 15956–16023MT-ND1m.3307A>T
MT-ND1 · protein-coding
protein tRNA rRNA D-loop
3D structure: where is this variant?
highlighted: residue 1 of MT-ND1 · drag to rotate, scroll to zoom.
General information
Variant ID MITHRIL.9921
MitImpact ID MI.10756
Chromosome chrM
Position 3307
Alleles (Ref/Alt) A/T
Molecule type protein-coding
Gene MT-ND1
Gene description mitochondrially encoded NADH:ubiquinone oxidoreductase core subunit 1
Gene (start-end) 3307-4262
Position within gene 1
Strand +
HGVS NC_012920.1:m.3307A>T
Functional effect Start lost
Respiratory chain complex I
External identifiers
Ensembl gene ENSG00000198888
Ensembl transcript ENST00000361390
Ensembl protein ENSP00000354687
UniProt NU1M_HUMAN (P03886)
NCBI gene 4535
NCBI protein YP_003024026.1
OMIM 516000
HGNC HGNC:7455
dbSNP rs1603218882
MITOMAP allele 3307A>T
Phylogenetic conservation
PhyloP (100V) 3.333
PhastCons (100V) 0.981
PhyloP (470-way) 0.58
PhastCons (470-way) 0.225
Amino-acid change
Codon substitution ATA/TTA
Reference AA M
Alternate AA L
AA position 1
Pathogenicity predictors
PolyPhen-2 Probably damaging
SIFT Deleterious
SIFT4G Neutral
PROVEAN Neutral
MutationTaster Disease causing
EFIN (SwissProt) Neutral
EFIN (HumDiv) Deleterious
LIST-S2 Deleterious
ESM1b Neutral
SNPDryad Neutral
Mitoclass1 Neutral
CADD Neutral
VEST Neutral
MLC Deleterious
Meta-predictors
APOGEE1 Deleterious
APOGEE2 VUS-
CAROL Deleterious
Condel Neutral
COVEC WMV Deleterious
MToolBox Deleterious
DEOGEN2 Neutral
Cancer-specific predictors
CHASM Neutral
Clinical significance & phenotype
ClinVar significance Uncertain significance
ClinVar disease
  • Leigh syndrome
ClinVar ID (allele ID) 692328 (680864)
ClinVar disease DB
ClinVar submitter IDs
Allele frequencies
MITOMAP known variant True
MITOMAP GenBank freq (seqs) 0 (0)
Residue interaction & stability
ΔΔG intra MT-ND1:M1L:I166F:1.36476:0.192435:1.16217;MT-ND1:M1L:I166V:0.661174:0.192435:0.715933;MT-ND1:M1L:I166M:-0.418223:0.192435:-0.594445;MT-ND1:M1L:I166T:0.84114:0.192435:0.604375;MT-ND1:M1L:I166S:0.937385:0.192435:0.970766;MT-ND1:M1L:I166L:-0.179628:0.192435:-0.420996;MT-ND1:M1L:I166N:1.93474:0.192435:1.63769;MT-ND1:M1L:A201G:0.862901:0.192435:0.725;MT-ND1:M1L:A201P:-0.656027:0.192435:-0.598678;MT-ND1:M1L:A201V:2.62898:0.192435:2.44106;MT-ND1:M1L:A201T:3.40554:0.192435:3.20878;MT-ND1:M1L:A201D:4.71536:0.192435:4.42968;MT-ND1:M1L:A201S:0.474202:0.192435:0.373424;MT-ND1:M1L:A249V:0.617033:0.192435:0.387706;MT-ND1:M1L:A249P:-0.77212:0.192435:-0.969457;MT-ND1:M1L:A249E:0.257047:0.192435:-0.081467;MT-ND1:M1L:A249G:0.477486:0.192435:0.24999;MT-ND1:M1L:A249T:0.779175:0.192435:0.585672;MT-ND1:M1L:A249S:0.635345:0.192435:0.416877;MT-ND1:M1L:P2R:0.900436:0.192435:0.63914;MT-ND1:M1L:P2H:1.04822:0.192435:0.926272;MT-ND1:M1L:P2L:0.33879:0.192435:0.109703;MT-ND1:M1L:P2T:0.36449:0.192435:0.178692;MT-ND1:M1L:P2A:0.613412:0.192435:0.449523;MT-ND1:M1L:P2S:0.21351:0.192435:0.119094;MT-ND1:M1L:M3V:1.05132:0.192435:0.898191;MT-ND1:M1L:M3T:1.55474:0.192435:1.3373;MT-ND1:M1L:M3I:0.527411:0.192435:0.24161;MT-ND1:M1L:M3K:0.720049:0.192435:0.647219;MT-ND1:M1L:M3L:0.255773:0.192435:0.320405
ΔΔG intra-interface MT-ND1:NDUFA1:5lc5:H:a:M1L:A249E:1.38641:1.35322:0.01115;MT-ND1:NDUFA1:5lc5:H:a:M1L:A249G:1.44097:1.35322:-0.0572;MT-ND1:NDUFA1:5lc5:H:a:M1L:A249P:1.51825:1.35322:-0.00503;MT-ND1:NDUFA1:5lc5:H:a:M1L:A249S:1.2709:1.35322:-0.08213;MT-ND1:NDUFA1:5lc5:H:a:M1L:A249T:1.6929:1.35322:0.19588;MT-ND1:NDUFA1:5lc5:H:a:M1L:A249V:1.3148:1.35322:0.16957;MT-ND1:NDUFA1:5ldw:H:a:M1L:A249E:0.67155:0.9567:0.02682;MT-ND1:NDUFA1:5ldw:H:a:M1L:A249G:1.14673:0.9567:0.38432;MT-ND1:NDUFA1:5ldw:H:a:M1L:A249P:0.56007:0.9567:-0.0544;MT-ND1:NDUFA1:5ldw:H:a:M1L:A249S:0.17561:0.9567:-0.69158;MT-ND1:NDUFA1:5ldw:H:a:M1L:A249T:0.80157:0.9567:0.24228;MT-ND1:NDUFA1:5ldw:H:a:M1L:A249V:1.14937:0.9567:0.18985
Intra-protein co-variation
1 ↔ 4: 32.9132 (mfDCA)1 ↔ 175: 30.1899 (mfDCA)1 ↔ 2: 29.9569 (mfDCA)1 ↔ 239: 27.6626 (mfDCA)1 ↔ 239: 27.6626 (mfDCA)1 ↔ 263: 27.31 (mfDCA)1 ↔ 9: 26.4013 (cMI)1 ↔ 300: 23.2395 (mfDCA)1 ↔ 3: 23.1959 (mfDCA)1 ↔ 3: 23.1959 (mfDCA)1 ↔ 166: 22.8794 (mfDCA)1 ↔ 166: 22.8794 (mfDCA)1 ↔ 5: 20.0005 (cMI)1 ↔ 201: 18.6094 (mfDCA)1 ↔ 10: 17.4958 (cMI)1 ↔ 14: 17.3247 (cMI)1 ↔ 249: 14.8015 (mfDCA)1 ↔ 12: 13.6194 (cMI)1 ↔ 4: 32.9132 (mfDCA)432.91321 ↔ 175: 30.1899 (mfDCA)17530.18991 ↔ 2: 29.9569 (mfDCA)229.95691 ↔ 239: 27.6626 (mfDCA)23927.66261 ↔ 239: 27.6626 (mfDCA)23927.66261 ↔ 263: 27.31 (mfDCA)26327.311 ↔ 9: 26.4013 (cMI)926.40131 ↔ 300: 23.2395 (mfDCA)30023.23951 ↔ 3: 23.1959 (mfDCA)323.19591 ↔ 3: 23.1959 (mfDCA)323.19591 ↔ 166: 22.8794 (mfDCA)16622.87941 ↔ 166: 22.8794 (mfDCA)16622.87941 ↔ 5: 20.0005 (cMI)520.00051 ↔ 201: 18.6094 (mfDCA)20118.60941 ↔ 10: 17.4958 (cMI)1017.49581 ↔ 14: 17.3247 (cMI)1417.32471 ↔ 249: 14.8015 (mfDCA)24914.80151 ↔ 12: 13.6194 (cMI)1213.619411

Same protein (MT-ND1); edge ∝ covariation score.

Show all 18 as text
  • 4: 32.9132 (mfDCA)
  • 175: 30.1899 (mfDCA)
  • 2: 29.9569 (mfDCA)
  • 239: 27.6626 (mfDCA)
  • 239: 27.6626 (mfDCA)
  • 263: 27.31 (mfDCA)
  • 9: 26.4013 (cMI)
  • 300: 23.2395 (mfDCA)
  • 3: 23.1959 (mfDCA)
  • 3: 23.1959 (mfDCA)
  • 166: 22.8794 (mfDCA)
  • 166: 22.8794 (mfDCA)
  • 5: 20.0005 (cMI)
  • 201: 18.6094 (mfDCA)
  • 10: 17.4958 (cMI)
  • 14: 17.3247 (cMI)
  • 249: 14.8015 (mfDCA)
  • 12: 13.6194 (cMI)
MT-ND1 · c.1A>G (p.Met1Val) protein-coding
Genome location
D-loop · dloop · 16024–16569D-loop · dloop · 1–576MT-TF · tRNA · 577–647MT-RNR1 · rRNA · 648–1601MT-TV · tRNA · 1602–1670MT-RNR2 · rRNA · 1671–3229MT-TL1 · tRNA · 3230–3304MT-ND1 · protein · 3307–4262MT-TI · tRNA · 4263–4331MT-TQ · tRNA · 4329–4400MT-TM · tRNA · 4402–4469MT-ND2 · protein · 4470–5511MT-TW · tRNA · 5512–5579MT-TA · tRNA · 5587–5655MT-TN · tRNA · 5657–5729MT-TC · tRNA · 5761–5826MT-TY · tRNA · 5826–5891MT-CO1 · protein · 5904–7445MT-TS1 · tRNA · 7446–7514MT-TD · tRNA · 7518–7585MT-CO2 · protein · 7586–8269MT-TK · tRNA · 8295–8364MT-ATP8 · protein · 8366–8572MT-ATP6 · protein · 8527–9207MT-CO3 · protein · 9207–9990MT-TG · tRNA · 9991–10058MT-ND3 · protein · 10059–10404MT-TR · tRNA · 10405–10469MT-ND4L · protein · 10470–10766MT-ND4 · protein · 10760–12137MT-TH · tRNA · 12138–12206MT-TS2 · tRNA · 12207–12265MT-TL2 · tRNA · 12266–12336MT-ND5 · protein · 12337–14148MT-ND6 · protein · 14149–14673MT-TE · tRNA · 14674–14742MT-CYB · protein · 14747–15887MT-TT · tRNA · 15888–15953MT-TP · tRNA · 15956–16023MT-ND1m.3307A>G
MT-ND1 · protein-coding
protein tRNA rRNA D-loop
3D structure: where is this variant?
highlighted: residue 1 of MT-ND1 · drag to rotate, scroll to zoom.
General information
Variant ID MITHRIL.9920
MitImpact ID MI.10757
Chromosome chrM
Position 3307
Alleles (Ref/Alt) A/G
Molecule type protein-coding
Gene MT-ND1
Gene description mitochondrially encoded NADH:ubiquinone oxidoreductase core subunit 1
Gene (start-end) 3307-4262
Position within gene 1
Strand +
HGVS NC_012920.1:m.3307A>G
Functional effect Start lost
Respiratory chain complex I
External identifiers
Ensembl gene ENSG00000198888
Ensembl transcript ENST00000361390
Ensembl protein ENSP00000354687
UniProt NU1M_HUMAN (P03886)
NCBI gene 4535
NCBI protein YP_003024026.1
OMIM 516000
HGNC HGNC:7455
dbSNP rs1603218882
MITOMAP allele 3307A>G
Phylogenetic conservation
PhyloP (100V) 3.333
PhastCons (100V) 0.981
PhyloP (470-way) 0.58
PhastCons (470-way) 0.225
Amino-acid change
Codon substitution ATA/GTA
Reference AA M
Alternate AA V
AA position 1
Pathogenicity predictors
PolyPhen-2 Probably damaging
SIFT Deleterious
SIFT4G Deleterious
PROVEAN Neutral
MutationTaster Disease causing
EFIN (SwissProt) Neutral
EFIN (HumDiv) Deleterious
LIST-S2 Deleterious
ESM1b Deleterious
SNPDryad Neutral
Mitoclass1 Neutral
CADD Neutral
VEST Neutral
MLC Deleterious
Meta-predictors
APOGEE1 Neutral
APOGEE2 VUS-
CAROL Deleterious
Condel Neutral
COVEC WMV Deleterious
MToolBox Deleterious
DEOGEN2 Neutral
Cancer-specific predictors
CHASM Neutral
Allele frequencies
MITOMAP known variant True
MITOMAP GenBank freq (seqs) 0 (0)
HelixMTdb hom AF (AC) 0 (1)
HelixMTdb het AF (AC) 0 (2)
HelixMTdb mean (max) ARF 0.2725 (0.3143)
ToMMo 61KJPN AF (AC) 0.0001 (7)
ToMMo 61KJPN AN 61424
Residue interaction & stability
ΔΔG intra MT-ND1:M1V:I166M:0.277031:0.759875:-0.594445;MT-ND1:M1V:I166S:1.7578:0.759875:0.970766;MT-ND1:M1V:I166V:1.40747:0.759875:0.715933;MT-ND1:M1V:I166N:2.31538:0.759875:1.63769;MT-ND1:M1V:I166L:0.418773:0.759875:-0.420996;MT-ND1:M1V:I166T:1.378:0.759875:0.604375;MT-ND1:M1V:I166F:2.75275:0.759875:1.16217;MT-ND1:M1V:A201S:0.915995:0.759875:0.373424;MT-ND1:M1V:A201G:1.49446:0.759875:0.725;MT-ND1:M1V:A201T:4.08641:0.759875:3.20878;MT-ND1:M1V:A201P:0.270235:0.759875:-0.598678;MT-ND1:M1V:A201V:2.83817:0.759875:2.44106;MT-ND1:M1V:A201D:5.29905:0.759875:4.42968;MT-ND1:M1V:A249S:1.13875:0.759875:0.416877;MT-ND1:M1V:A249G:1.04452:0.759875:0.24999;MT-ND1:M1V:A249P:-0.167069:0.759875:-0.969457;MT-ND1:M1V:A249E:0.742468:0.759875:-0.081467;MT-ND1:M1V:A249T:1.38222:0.759875:0.585672;MT-ND1:M1V:A249V:1.17759:0.759875:0.387706;MT-ND1:M1V:P2L:0.659442:0.759875:0.109703;MT-ND1:M1V:P2S:0.76812:0.759875:0.119094;MT-ND1:M1V:P2H:1.44649:0.759875:0.926272;MT-ND1:M1V:P2A:1.07527:0.759875:0.449523;MT-ND1:M1V:P2T:0.801573:0.759875:0.178692;MT-ND1:M1V:P2R:1.35817:0.759875:0.63914;MT-ND1:M1V:M3L:0.863955:0.759875:0.320405;MT-ND1:M1V:M3T:1.87594:0.759875:1.3373;MT-ND1:M1V:M3I:0.977522:0.759875:0.24161;MT-ND1:M1V:M3V:1.56252:0.759875:0.898191;MT-ND1:M1V:M3K:1.3029:0.759875:0.647219
ΔΔG intra-interface MT-ND1:NDUFA1:5lc5:H:a:M1V:A249E:1.409:1.30255:0.01115;MT-ND1:NDUFA1:5lc5:H:a:M1V:A249G:1.23839:1.30255:-0.0572;MT-ND1:NDUFA1:5lc5:H:a:M1V:A249P:1.40141:1.30255:-0.00503;MT-ND1:NDUFA1:5lc5:H:a:M1V:A249S:1.17536:1.30255:-0.08213;MT-ND1:NDUFA1:5lc5:H:a:M1V:A249T:1.49079:1.30255:0.19588;MT-ND1:NDUFA1:5lc5:H:a:M1V:A249V:1.55048:1.30255:0.16957;MT-ND1:NDUFA1:5ldw:H:a:M1V:A249E:0.78826:0.61909:0.02682;MT-ND1:NDUFA1:5ldw:H:a:M1V:A249G:1.29683:0.61909:0.38432;MT-ND1:NDUFA1:5ldw:H:a:M1V:A249P:0.82579:0.61909:-0.0544;MT-ND1:NDUFA1:5ldw:H:a:M1V:A249S:-0.23898:0.61909:-0.69158;MT-ND1:NDUFA1:5ldw:H:a:M1V:A249T:0.602:0.61909:0.24228;MT-ND1:NDUFA1:5ldw:H:a:M1V:A249V:0.64306:0.61909:0.18985
Intra-protein co-variation
1 ↔ 4: 32.9132 (mfDCA)1 ↔ 175: 30.1899 (mfDCA)1 ↔ 2: 29.9569 (mfDCA)1 ↔ 239: 27.6626 (mfDCA)1 ↔ 239: 27.6626 (mfDCA)1 ↔ 263: 27.31 (mfDCA)1 ↔ 9: 26.4013 (cMI)1 ↔ 300: 23.2395 (mfDCA)1 ↔ 3: 23.1959 (mfDCA)1 ↔ 3: 23.1959 (mfDCA)1 ↔ 166: 22.8794 (mfDCA)1 ↔ 166: 22.8794 (mfDCA)1 ↔ 5: 20.0005 (cMI)1 ↔ 201: 18.6094 (mfDCA)1 ↔ 10: 17.4958 (cMI)1 ↔ 14: 17.3247 (cMI)1 ↔ 249: 14.8015 (mfDCA)1 ↔ 12: 13.6194 (cMI)1 ↔ 4: 32.9132 (mfDCA)432.91321 ↔ 175: 30.1899 (mfDCA)17530.18991 ↔ 2: 29.9569 (mfDCA)229.95691 ↔ 239: 27.6626 (mfDCA)23927.66261 ↔ 239: 27.6626 (mfDCA)23927.66261 ↔ 263: 27.31 (mfDCA)26327.311 ↔ 9: 26.4013 (cMI)926.40131 ↔ 300: 23.2395 (mfDCA)30023.23951 ↔ 3: 23.1959 (mfDCA)323.19591 ↔ 3: 23.1959 (mfDCA)323.19591 ↔ 166: 22.8794 (mfDCA)16622.87941 ↔ 166: 22.8794 (mfDCA)16622.87941 ↔ 5: 20.0005 (cMI)520.00051 ↔ 201: 18.6094 (mfDCA)20118.60941 ↔ 10: 17.4958 (cMI)1017.49581 ↔ 14: 17.3247 (cMI)1417.32471 ↔ 249: 14.8015 (mfDCA)24914.80151 ↔ 12: 13.6194 (cMI)1213.619411

Same protein (MT-ND1); edge ∝ covariation score.

Show all 18 as text
  • 4: 32.9132 (mfDCA)
  • 175: 30.1899 (mfDCA)
  • 2: 29.9569 (mfDCA)
  • 239: 27.6626 (mfDCA)
  • 239: 27.6626 (mfDCA)
  • 263: 27.31 (mfDCA)
  • 9: 26.4013 (cMI)
  • 300: 23.2395 (mfDCA)
  • 3: 23.1959 (mfDCA)
  • 3: 23.1959 (mfDCA)
  • 166: 22.8794 (mfDCA)
  • 166: 22.8794 (mfDCA)
  • 5: 20.0005 (cMI)
  • 201: 18.6094 (mfDCA)
  • 10: 17.4958 (cMI)
  • 14: 17.3247 (cMI)
  • 249: 14.8015 (mfDCA)
  • 12: 13.6194 (cMI)
MT-ND1 · c.2T>A (p.Met1Lys) protein-coding
Genome location
D-loop · dloop · 16024–16569D-loop · dloop · 1–576MT-TF · tRNA · 577–647MT-RNR1 · rRNA · 648–1601MT-TV · tRNA · 1602–1670MT-RNR2 · rRNA · 1671–3229MT-TL1 · tRNA · 3230–3304MT-ND1 · protein · 3307–4262MT-TI · tRNA · 4263–4331MT-TQ · tRNA · 4329–4400MT-TM · tRNA · 4402–4469MT-ND2 · protein · 4470–5511MT-TW · tRNA · 5512–5579MT-TA · tRNA · 5587–5655MT-TN · tRNA · 5657–5729MT-TC · tRNA · 5761–5826MT-TY · tRNA · 5826–5891MT-CO1 · protein · 5904–7445MT-TS1 · tRNA · 7446–7514MT-TD · tRNA · 7518–7585MT-CO2 · protein · 7586–8269MT-TK · tRNA · 8295–8364MT-ATP8 · protein · 8366–8572MT-ATP6 · protein · 8527–9207MT-CO3 · protein · 9207–9990MT-TG · tRNA · 9991–10058MT-ND3 · protein · 10059–10404MT-TR · tRNA · 10405–10469MT-ND4L · protein · 10470–10766MT-ND4 · protein · 10760–12137MT-TH · tRNA · 12138–12206MT-TS2 · tRNA · 12207–12265MT-TL2 · tRNA · 12266–12336MT-ND5 · protein · 12337–14148MT-ND6 · protein · 14149–14673MT-TE · tRNA · 14674–14742MT-CYB · protein · 14747–15887MT-TT · tRNA · 15888–15953MT-TP · tRNA · 15956–16023MT-ND1m.3308T>A
MT-ND1 · protein-coding
protein tRNA rRNA D-loop
3D structure: where is this variant?
highlighted: residue 1 of MT-ND1 · drag to rotate, scroll to zoom.
General information
Variant ID MITHRIL.9922
MitImpact ID MI.10759
Chromosome chrM
Position 3308
Alleles (Ref/Alt) T/A
Molecule type protein-coding
Gene MT-ND1
Gene description mitochondrially encoded NADH:ubiquinone oxidoreductase core subunit 1
Gene (start-end) 3307-4262
Position within gene 2
Strand +
HGVS NC_012920.1:m.3308T>A
Functional effect Start lost
Respiratory chain complex I
External identifiers
Ensembl gene ENSG00000198888
Ensembl transcript ENST00000361390
Ensembl protein ENSP00000354687
UniProt NU1M_HUMAN (P03886)
NCBI gene 4535
NCBI protein YP_003024026.1
OMIM 516000
HGNC HGNC:7455
MITOMAP allele 3308T>A
Phylogenetic conservation
PhyloP (100V) 4.722
PhastCons (100V) 1
PhyloP (470-way) 0.458
PhastCons (470-way) 0.156
Amino-acid change
Codon substitution ATA/AAA
Reference AA M
Alternate AA K
AA position 1
Pathogenicity predictors
PolyPhen-2 Probably damaging
SIFT Deleterious
SIFT4G Deleterious
PROVEAN Neutral
MutationTaster Polymorphism
EFIN (SwissProt) Deleterious
EFIN (HumDiv) Deleterious
LIST-S2 Deleterious
ESM1b Deleterious
SNPDryad Neutral
Mitoclass1 Deleterious
CADD Deleterious
VEST Neutral
MLC Deleterious
Meta-predictors
APOGEE1 Deleterious
APOGEE2 VUS
CAROL Deleterious
Condel Neutral
COVEC WMV Deleterious
MToolBox Deleterious
DEOGEN2 Neutral
Cancer-specific predictors
CHASM Neutral
Allele frequencies
MITOMAP known variant True
MITOMAP GenBank freq (seqs) 0.0015 (1)
gnomAD hom AF (AC) 0 (0)
gnomAD het AF (AC) 0 (1)
gnomAD AN 56434
gnomAD filter PASS
Residue interaction & stability
ΔΔG intra MT-ND1:M1K:I166V:1.2141:0.544385:0.715933;MT-ND1:M1K:I166F:2.26877:0.544385:1.16217;MT-ND1:M1K:I166S:1.50615:0.544385:0.970766;MT-ND1:M1K:I166N:2.17919:0.544385:1.63769;MT-ND1:M1K:I166M:-0.0330956:0.544385:-0.594445;MT-ND1:M1K:I166T:1.16283:0.544385:0.604375;MT-ND1:M1K:I166L:0.101128:0.544385:-0.420996;MT-ND1:M1K:A201T:3.91511:0.544385:3.20878;MT-ND1:M1K:A201V:3.03479:0.544385:2.44106;MT-ND1:M1K:A201P:-0.0711865:0.544385:-0.598678;MT-ND1:M1K:A201S:0.864929:0.544385:0.373424;MT-ND1:M1K:A201G:1.33827:0.544385:0.725;MT-ND1:M1K:A201D:5.12657:0.544385:4.42968;MT-ND1:M1K:A249P:-0.435081:0.544385:-0.969457;MT-ND1:M1K:A249T:1.14379:0.544385:0.585672;MT-ND1:M1K:A249V:0.960045:0.544385:0.387706;MT-ND1:M1K:A249G:0.821539:0.544385:0.24999;MT-ND1:M1K:A249E:0.485493:0.544385:-0.081467;MT-ND1:M1K:A249S:0.990487:0.544385:0.416877;MT-ND1:M1K:P2S:0.506443:0.544385:0.119094;MT-ND1:M1K:P2R:1.07653:0.544385:0.63914;MT-ND1:M1K:P2H:1.28887:0.544385:0.926272;MT-ND1:M1K:P2L:0.48012:0.544385:0.109703;MT-ND1:M1K:P2T:0.593396:0.544385:0.178692;MT-ND1:M1K:P2A:0.828089:0.544385:0.449523;MT-ND1:M1K:M3T:1.45824:0.544385:1.3373;MT-ND1:M1K:M3V:1.13507:0.544385:0.898191;MT-ND1:M1K:M3L:0.829577:0.544385:0.320405;MT-ND1:M1K:M3K:1.14476:0.544385:0.647219;MT-ND1:M1K:M3I:0.559036:0.544385:0.24161
ΔΔG intra-interface MT-ND1:NDUFA1:5lc5:H:a:M1K:A249E:1.31765:1.21844:0.01115;MT-ND1:NDUFA1:5lc5:H:a:M1K:A249G:0.89961:1.21844:-0.0572;MT-ND1:NDUFA1:5lc5:H:a:M1K:A249P:1.32201:1.21844:-0.00503;MT-ND1:NDUFA1:5lc5:H:a:M1K:A249S:0.93127:1.21844:-0.08213;MT-ND1:NDUFA1:5lc5:H:a:M1K:A249T:1.43994:1.21844:0.19588;MT-ND1:NDUFA1:5lc5:H:a:M1K:A249V:1.57422:1.21844:0.16957;MT-ND1:NDUFA1:5ldw:H:a:M1K:A249E:0.28214:0.39346:0.02682;MT-ND1:NDUFA1:5ldw:H:a:M1K:A249G:0.91338:0.39346:0.38432;MT-ND1:NDUFA1:5ldw:H:a:M1K:A249P:0.46572:0.39346:-0.0544;MT-ND1:NDUFA1:5ldw:H:a:M1K:A249S:0.33555:0.39346:-0.69158;MT-ND1:NDUFA1:5ldw:H:a:M1K:A249T:0.67256:0.39346:0.24228;MT-ND1:NDUFA1:5ldw:H:a:M1K:A249V:0.65565:0.39346:0.18985
Intra-protein co-variation
1 ↔ 4: 32.9132 (mfDCA)1 ↔ 175: 30.1899 (mfDCA)1 ↔ 2: 29.9569 (mfDCA)1 ↔ 239: 27.6626 (mfDCA)1 ↔ 239: 27.6626 (mfDCA)1 ↔ 263: 27.31 (mfDCA)1 ↔ 9: 26.4013 (cMI)1 ↔ 300: 23.2395 (mfDCA)1 ↔ 3: 23.1959 (mfDCA)1 ↔ 3: 23.1959 (mfDCA)1 ↔ 166: 22.8794 (mfDCA)1 ↔ 166: 22.8794 (mfDCA)1 ↔ 5: 20.0005 (cMI)1 ↔ 201: 18.6094 (mfDCA)1 ↔ 10: 17.4958 (cMI)1 ↔ 14: 17.3247 (cMI)1 ↔ 249: 14.8015 (mfDCA)1 ↔ 12: 13.6194 (cMI)1 ↔ 4: 32.9132 (mfDCA)432.91321 ↔ 175: 30.1899 (mfDCA)17530.18991 ↔ 2: 29.9569 (mfDCA)229.95691 ↔ 239: 27.6626 (mfDCA)23927.66261 ↔ 239: 27.6626 (mfDCA)23927.66261 ↔ 263: 27.31 (mfDCA)26327.311 ↔ 9: 26.4013 (cMI)926.40131 ↔ 300: 23.2395 (mfDCA)30023.23951 ↔ 3: 23.1959 (mfDCA)323.19591 ↔ 3: 23.1959 (mfDCA)323.19591 ↔ 166: 22.8794 (mfDCA)16622.87941 ↔ 166: 22.8794 (mfDCA)16622.87941 ↔ 5: 20.0005 (cMI)520.00051 ↔ 201: 18.6094 (mfDCA)20118.60941 ↔ 10: 17.4958 (cMI)1017.49581 ↔ 14: 17.3247 (cMI)1417.32471 ↔ 249: 14.8015 (mfDCA)24914.80151 ↔ 12: 13.6194 (cMI)1213.619411

Same protein (MT-ND1); edge ∝ covariation score.

Show all 18 as text
  • 4: 32.9132 (mfDCA)
  • 175: 30.1899 (mfDCA)
  • 2: 29.9569 (mfDCA)
  • 239: 27.6626 (mfDCA)
  • 239: 27.6626 (mfDCA)
  • 263: 27.31 (mfDCA)
  • 9: 26.4013 (cMI)
  • 300: 23.2395 (mfDCA)
  • 3: 23.1959 (mfDCA)
  • 3: 23.1959 (mfDCA)
  • 166: 22.8794 (mfDCA)
  • 166: 22.8794 (mfDCA)
  • 5: 20.0005 (cMI)
  • 201: 18.6094 (mfDCA)
  • 10: 17.4958 (cMI)
  • 14: 17.3247 (cMI)
  • 249: 14.8015 (mfDCA)
  • 12: 13.6194 (cMI)
MT-ND1 · c.3A>C (p.Met1Ile) protein-coding
Genome location
D-loop · dloop · 16024–16569D-loop · dloop · 1–576MT-TF · tRNA · 577–647MT-RNR1 · rRNA · 648–1601MT-TV · tRNA · 1602–1670MT-RNR2 · rRNA · 1671–3229MT-TL1 · tRNA · 3230–3304MT-ND1 · protein · 3307–4262MT-TI · tRNA · 4263–4331MT-TQ · tRNA · 4329–4400MT-TM · tRNA · 4402–4469MT-ND2 · protein · 4470–5511MT-TW · tRNA · 5512–5579MT-TA · tRNA · 5587–5655MT-TN · tRNA · 5657–5729MT-TC · tRNA · 5761–5826MT-TY · tRNA · 5826–5891MT-CO1 · protein · 5904–7445MT-TS1 · tRNA · 7446–7514MT-TD · tRNA · 7518–7585MT-CO2 · protein · 7586–8269MT-TK · tRNA · 8295–8364MT-ATP8 · protein · 8366–8572MT-ATP6 · protein · 8527–9207MT-CO3 · protein · 9207–9990MT-TG · tRNA · 9991–10058MT-ND3 · protein · 10059–10404MT-TR · tRNA · 10405–10469MT-ND4L · protein · 10470–10766MT-ND4 · protein · 10760–12137MT-TH · tRNA · 12138–12206MT-TS2 · tRNA · 12207–12265MT-TL2 · tRNA · 12266–12336MT-ND5 · protein · 12337–14148MT-ND6 · protein · 14149–14673MT-TE · tRNA · 14674–14742MT-CYB · protein · 14747–15887MT-TT · tRNA · 15888–15953MT-TP · tRNA · 15956–16023MT-ND1m.3309A>C
MT-ND1 · protein-coding
protein tRNA rRNA D-loop
3D structure: where is this variant?
highlighted: residue 1 of MT-ND1 · drag to rotate, scroll to zoom.
General information
Variant ID MITHRIL.9925
MitImpact ID MI.10761
Chromosome chrM
Position 3309
Alleles (Ref/Alt) A/C
Molecule type protein-coding
Gene MT-ND1
Gene description mitochondrially encoded NADH:ubiquinone oxidoreductase core subunit 1
Gene (start-end) 3307-4262
Position within gene 3
Strand +
HGVS NC_012920.1:m.3309A>C
Functional effect Initiator codon variant
Functional effect (detailed) Initiator codon variant;WARNING
Respiratory chain complex I
External identifiers
Ensembl gene ENSG00000198888
Ensembl transcript ENST00000361390
Ensembl protein ENSP00000354687
UniProt NU1M_HUMAN (P03886)
NCBI gene 4535
NCBI protein YP_003024026.1
OMIM 516000
HGNC HGNC:7455
MITOMAP allele 3309A>C
Phylogenetic conservation
PhyloP (100V) 3.182
PhastCons (100V) 1
PhyloP (470-way) -0.331
PhastCons (470-way) 0.057
Amino-acid change
Codon substitution ATA/ATC
Reference AA M
Alternate AA I
AA position 1
Pathogenicity predictors
PolyPhen-2 Probably damaging
SIFT Deleterious
SIFT4G Deleterious
PROVEAN Neutral
MutationTaster Disease causing
EFIN (SwissProt) Deleterious
EFIN (HumDiv) Deleterious
LIST-S2 Deleterious
ESM1b Neutral
SNPDryad Neutral
Mitoclass1 Neutral
CADD Neutral
VEST Neutral
MLC Deleterious
Meta-predictors
APOGEE1 Deleterious
APOGEE2 VUS-
CAROL Deleterious
Condel Neutral
COVEC WMV Deleterious
MToolBox Deleterious
DEOGEN2 Neutral
Cancer-specific predictors
CHASM Neutral
Allele frequencies
MITOMAP known variant False
Residue interaction & stability
ΔΔG intra MT-ND1:M1I:I166S:1.64091:0.696801:0.970766;MT-ND1:M1I:I166M:0.197699:0.696801:-0.594445;MT-ND1:M1I:I166F:2.75691:0.696801:1.16217;MT-ND1:M1I:I166L:0.331566:0.696801:-0.420996;MT-ND1:M1I:I166N:2.37462:0.696801:1.63769;MT-ND1:M1I:I166T:1.3133:0.696801:0.604375;MT-ND1:M1I:I166V:1.32601:0.696801:0.715933;MT-ND1:M1I:A201D:5.44404:0.696801:4.42968;MT-ND1:M1I:A201V:3.28086:0.696801:2.44106;MT-ND1:M1I:A201T:3.8683:0.696801:3.20878;MT-ND1:M1I:A201P:0.214743:0.696801:-0.598678;MT-ND1:M1I:A201G:1.46834:0.696801:0.725;MT-ND1:M1I:A201S:0.994439:0.696801:0.373424;MT-ND1:M1I:A249G:0.940721:0.696801:0.24999;MT-ND1:M1I:A249T:1.26725:0.696801:0.585672;MT-ND1:M1I:A249E:0.776841:0.696801:-0.081467;MT-ND1:M1I:A249V:1.12623:0.696801:0.387706;MT-ND1:M1I:A249P:-0.226368:0.696801:-0.969457;MT-ND1:M1I:A249S:1.16372:0.696801:0.416877;MT-ND1:M1I:P2S:0.664649:0.696801:0.119094;MT-ND1:M1I:P2H:1.3433:0.696801:0.926272;MT-ND1:M1I:P2L:0.510437:0.696801:0.109703;MT-ND1:M1I:P2A:0.945025:0.696801:0.449523;MT-ND1:M1I:P2R:1.28624:0.696801:0.63914;MT-ND1:M1I:P2T:0.706936:0.696801:0.178692;MT-ND1:M1I:M3I:0.912034:0.696801:0.24161;MT-ND1:M1I:M3K:1.29665:0.696801:0.647219;MT-ND1:M1I:M3L:0.83847:0.696801:0.320405;MT-ND1:M1I:M3T:1.8104:0.696801:1.3373;MT-ND1:M1I:M3V:1.4542:0.696801:0.898191
ΔΔG intra-interface MT-ND1:NDUFA1:5lc5:H:a:M1I:A249E:1.03311:1.05275:0.01115;MT-ND1:NDUFA1:5lc5:H:a:M1I:A249G:0.95399:1.05275:-0.0572;MT-ND1:NDUFA1:5lc5:H:a:M1I:A249P:0.98433:1.05275:-0.00503;MT-ND1:NDUFA1:5lc5:H:a:M1I:A249S:0.93231:1.05275:-0.08213;MT-ND1:NDUFA1:5lc5:H:a:M1I:A249T:1.07445:1.05275:0.19588;MT-ND1:NDUFA1:5lc5:H:a:M1I:A249V:1.29754:1.05275:0.16957;MT-ND1:NDUFA1:5ldw:H:a:M1I:A249E:0.31294:0.03068:0.02682;MT-ND1:NDUFA1:5ldw:H:a:M1I:A249G:0.84165:0.03068:0.38432;MT-ND1:NDUFA1:5ldw:H:a:M1I:A249P:0.65404:0.03068:-0.0544;MT-ND1:NDUFA1:5ldw:H:a:M1I:A249S:-0.46109:0.03068:-0.69158;MT-ND1:NDUFA1:5ldw:H:a:M1I:A249T:0.54385:0.03068:0.24228;MT-ND1:NDUFA1:5ldw:H:a:M1I:A249V:0.46123:0.03068:0.18985
Intra-protein co-variation
1 ↔ 4: 32.9132 (mfDCA)1 ↔ 175: 30.1899 (mfDCA)1 ↔ 2: 29.9569 (mfDCA)1 ↔ 239: 27.6626 (mfDCA)1 ↔ 239: 27.6626 (mfDCA)1 ↔ 263: 27.31 (mfDCA)1 ↔ 9: 26.4013 (cMI)1 ↔ 300: 23.2395 (mfDCA)1 ↔ 3: 23.1959 (mfDCA)1 ↔ 3: 23.1959 (mfDCA)1 ↔ 166: 22.8794 (mfDCA)1 ↔ 166: 22.8794 (mfDCA)1 ↔ 5: 20.0005 (cMI)1 ↔ 201: 18.6094 (mfDCA)1 ↔ 10: 17.4958 (cMI)1 ↔ 14: 17.3247 (cMI)1 ↔ 249: 14.8015 (mfDCA)1 ↔ 12: 13.6194 (cMI)1 ↔ 4: 32.9132 (mfDCA)432.91321 ↔ 175: 30.1899 (mfDCA)17530.18991 ↔ 2: 29.9569 (mfDCA)229.95691 ↔ 239: 27.6626 (mfDCA)23927.66261 ↔ 239: 27.6626 (mfDCA)23927.66261 ↔ 263: 27.31 (mfDCA)26327.311 ↔ 9: 26.4013 (cMI)926.40131 ↔ 300: 23.2395 (mfDCA)30023.23951 ↔ 3: 23.1959 (mfDCA)323.19591 ↔ 3: 23.1959 (mfDCA)323.19591 ↔ 166: 22.8794 (mfDCA)16622.87941 ↔ 166: 22.8794 (mfDCA)16622.87941 ↔ 5: 20.0005 (cMI)520.00051 ↔ 201: 18.6094 (mfDCA)20118.60941 ↔ 10: 17.4958 (cMI)1017.49581 ↔ 14: 17.3247 (cMI)1417.32471 ↔ 249: 14.8015 (mfDCA)24914.80151 ↔ 12: 13.6194 (cMI)1213.619411

Same protein (MT-ND1); edge ∝ covariation score.

Show all 18 as text
  • 4: 32.9132 (mfDCA)
  • 175: 30.1899 (mfDCA)
  • 2: 29.9569 (mfDCA)
  • 239: 27.6626 (mfDCA)
  • 239: 27.6626 (mfDCA)
  • 263: 27.31 (mfDCA)
  • 9: 26.4013 (cMI)
  • 300: 23.2395 (mfDCA)
  • 3: 23.1959 (mfDCA)
  • 3: 23.1959 (mfDCA)
  • 166: 22.8794 (mfDCA)
  • 166: 22.8794 (mfDCA)
  • 5: 20.0005 (cMI)
  • 201: 18.6094 (mfDCA)
  • 10: 17.4958 (cMI)
  • 14: 17.3247 (cMI)
  • 249: 14.8015 (mfDCA)
  • 12: 13.6194 (cMI)
MT-ND1 · c.3A>T (p.Met1Ile) protein-coding
Genome location
D-loop · dloop · 16024–16569D-loop · dloop · 1–576MT-TF · tRNA · 577–647MT-RNR1 · rRNA · 648–1601MT-TV · tRNA · 1602–1670MT-RNR2 · rRNA · 1671–3229MT-TL1 · tRNA · 3230–3304MT-ND1 · protein · 3307–4262MT-TI · tRNA · 4263–4331MT-TQ · tRNA · 4329–4400MT-TM · tRNA · 4402–4469MT-ND2 · protein · 4470–5511MT-TW · tRNA · 5512–5579MT-TA · tRNA · 5587–5655MT-TN · tRNA · 5657–5729MT-TC · tRNA · 5761–5826MT-TY · tRNA · 5826–5891MT-CO1 · protein · 5904–7445MT-TS1 · tRNA · 7446–7514MT-TD · tRNA · 7518–7585MT-CO2 · protein · 7586–8269MT-TK · tRNA · 8295–8364MT-ATP8 · protein · 8366–8572MT-ATP6 · protein · 8527–9207MT-CO3 · protein · 9207–9990MT-TG · tRNA · 9991–10058MT-ND3 · protein · 10059–10404MT-TR · tRNA · 10405–10469MT-ND4L · protein · 10470–10766MT-ND4 · protein · 10760–12137MT-TH · tRNA · 12138–12206MT-TS2 · tRNA · 12207–12265MT-TL2 · tRNA · 12266–12336MT-ND5 · protein · 12337–14148MT-ND6 · protein · 14149–14673MT-TE · tRNA · 14674–14742MT-CYB · protein · 14747–15887MT-TT · tRNA · 15888–15953MT-TP · tRNA · 15956–16023MT-ND1m.3309A>T
MT-ND1 · protein-coding
protein tRNA rRNA D-loop
3D structure: where is this variant?
highlighted: residue 1 of MT-ND1 · drag to rotate, scroll to zoom.
General information
Variant ID MITHRIL.9927
MitImpact ID MI.10760
Chromosome chrM
Position 3309
Alleles (Ref/Alt) A/T
Molecule type protein-coding
Gene MT-ND1
Gene description mitochondrially encoded NADH:ubiquinone oxidoreductase core subunit 1
Gene (start-end) 3307-4262
Position within gene 3
Strand +
HGVS NC_012920.1:m.3309A>T
Functional effect Initiator codon variant
Functional effect (detailed) Initiator codon variant;WARNING
Respiratory chain complex I
External identifiers
Ensembl gene ENSG00000198888
Ensembl transcript ENST00000361390
Ensembl protein ENSP00000354687
UniProt NU1M_HUMAN (P03886)
NCBI gene 4535
NCBI protein YP_003024026.1
OMIM 516000
HGNC HGNC:7455
MITOMAP allele 3309A>T
Phylogenetic conservation
PhyloP (100V) 3.182
PhastCons (100V) 1
PhyloP (470-way) -0.331
PhastCons (470-way) 0.057
Amino-acid change
Codon substitution ATA/ATT
Reference AA M
Alternate AA I
AA position 1
Pathogenicity predictors
PolyPhen-2 Probably damaging
SIFT Deleterious
SIFT4G Deleterious
PROVEAN Neutral
MutationTaster Disease causing
EFIN (SwissProt) Deleterious
EFIN (HumDiv) Deleterious
LIST-S2 Deleterious
ESM1b Neutral
SNPDryad Neutral
Mitoclass1 Neutral
CADD Neutral
VEST Neutral
MLC Deleterious
Meta-predictors
APOGEE1 Deleterious
APOGEE2 VUS-
CAROL Deleterious
Condel Neutral
COVEC WMV Deleterious
MToolBox Deleterious
DEOGEN2 Neutral
Cancer-specific predictors
CHASM Neutral
Allele frequencies
MITOMAP known variant True
MITOMAP GenBank freq (seqs) 0 (0)
HelixMTdb hom AF (AC) 0 (2)
HelixMTdb het AF (AC) 0 (0)
Residue interaction & stability
ΔΔG intra MT-ND1:M1I:I166S:1.64091:0.696801:0.970766;MT-ND1:M1I:I166M:0.197699:0.696801:-0.594445;MT-ND1:M1I:I166F:2.75691:0.696801:1.16217;MT-ND1:M1I:I166L:0.331566:0.696801:-0.420996;MT-ND1:M1I:I166N:2.37462:0.696801:1.63769;MT-ND1:M1I:I166T:1.3133:0.696801:0.604375;MT-ND1:M1I:I166V:1.32601:0.696801:0.715933;MT-ND1:M1I:A201D:5.44404:0.696801:4.42968;MT-ND1:M1I:A201V:3.28086:0.696801:2.44106;MT-ND1:M1I:A201T:3.8683:0.696801:3.20878;MT-ND1:M1I:A201P:0.214743:0.696801:-0.598678;MT-ND1:M1I:A201G:1.46834:0.696801:0.725;MT-ND1:M1I:A201S:0.994439:0.696801:0.373424;MT-ND1:M1I:A249G:0.940721:0.696801:0.24999;MT-ND1:M1I:A249T:1.26725:0.696801:0.585672;MT-ND1:M1I:A249E:0.776841:0.696801:-0.081467;MT-ND1:M1I:A249V:1.12623:0.696801:0.387706;MT-ND1:M1I:A249P:-0.226368:0.696801:-0.969457;MT-ND1:M1I:A249S:1.16372:0.696801:0.416877;MT-ND1:M1I:P2S:0.664649:0.696801:0.119094;MT-ND1:M1I:P2H:1.3433:0.696801:0.926272;MT-ND1:M1I:P2L:0.510437:0.696801:0.109703;MT-ND1:M1I:P2A:0.945025:0.696801:0.449523;MT-ND1:M1I:P2R:1.28624:0.696801:0.63914;MT-ND1:M1I:P2T:0.706936:0.696801:0.178692;MT-ND1:M1I:M3I:0.912034:0.696801:0.24161;MT-ND1:M1I:M3K:1.29665:0.696801:0.647219;MT-ND1:M1I:M3L:0.83847:0.696801:0.320405;MT-ND1:M1I:M3T:1.8104:0.696801:1.3373;MT-ND1:M1I:M3V:1.4542:0.696801:0.898191
ΔΔG intra-interface MT-ND1:NDUFA1:5lc5:H:a:M1I:A249E:1.03311:1.05275:0.01115;MT-ND1:NDUFA1:5lc5:H:a:M1I:A249G:0.95399:1.05275:-0.0572;MT-ND1:NDUFA1:5lc5:H:a:M1I:A249P:0.98433:1.05275:-0.00503;MT-ND1:NDUFA1:5lc5:H:a:M1I:A249S:0.93231:1.05275:-0.08213;MT-ND1:NDUFA1:5lc5:H:a:M1I:A249T:1.07445:1.05275:0.19588;MT-ND1:NDUFA1:5lc5:H:a:M1I:A249V:1.29754:1.05275:0.16957;MT-ND1:NDUFA1:5ldw:H:a:M1I:A249E:0.31294:0.03068:0.02682;MT-ND1:NDUFA1:5ldw:H:a:M1I:A249G:0.84165:0.03068:0.38432;MT-ND1:NDUFA1:5ldw:H:a:M1I:A249P:0.65404:0.03068:-0.0544;MT-ND1:NDUFA1:5ldw:H:a:M1I:A249S:-0.46109:0.03068:-0.69158;MT-ND1:NDUFA1:5ldw:H:a:M1I:A249T:0.54385:0.03068:0.24228;MT-ND1:NDUFA1:5ldw:H:a:M1I:A249V:0.46123:0.03068:0.18985
Intra-protein co-variation
1 ↔ 4: 32.9132 (mfDCA)1 ↔ 175: 30.1899 (mfDCA)1 ↔ 2: 29.9569 (mfDCA)1 ↔ 239: 27.6626 (mfDCA)1 ↔ 239: 27.6626 (mfDCA)1 ↔ 263: 27.31 (mfDCA)1 ↔ 9: 26.4013 (cMI)1 ↔ 300: 23.2395 (mfDCA)1 ↔ 3: 23.1959 (mfDCA)1 ↔ 3: 23.1959 (mfDCA)1 ↔ 166: 22.8794 (mfDCA)1 ↔ 166: 22.8794 (mfDCA)1 ↔ 5: 20.0005 (cMI)1 ↔ 201: 18.6094 (mfDCA)1 ↔ 10: 17.4958 (cMI)1 ↔ 14: 17.3247 (cMI)1 ↔ 249: 14.8015 (mfDCA)1 ↔ 12: 13.6194 (cMI)1 ↔ 4: 32.9132 (mfDCA)432.91321 ↔ 175: 30.1899 (mfDCA)17530.18991 ↔ 2: 29.9569 (mfDCA)229.95691 ↔ 239: 27.6626 (mfDCA)23927.66261 ↔ 239: 27.6626 (mfDCA)23927.66261 ↔ 263: 27.31 (mfDCA)26327.311 ↔ 9: 26.4013 (cMI)926.40131 ↔ 300: 23.2395 (mfDCA)30023.23951 ↔ 3: 23.1959 (mfDCA)323.19591 ↔ 3: 23.1959 (mfDCA)323.19591 ↔ 166: 22.8794 (mfDCA)16622.87941 ↔ 166: 22.8794 (mfDCA)16622.87941 ↔ 5: 20.0005 (cMI)520.00051 ↔ 201: 18.6094 (mfDCA)20118.60941 ↔ 10: 17.4958 (cMI)1017.49581 ↔ 14: 17.3247 (cMI)1417.32471 ↔ 249: 14.8015 (mfDCA)24914.80151 ↔ 12: 13.6194 (cMI)1213.619411

Same protein (MT-ND1); edge ∝ covariation score.

Show all 18 as text
  • 4: 32.9132 (mfDCA)
  • 175: 30.1899 (mfDCA)
  • 2: 29.9569 (mfDCA)
  • 239: 27.6626 (mfDCA)
  • 239: 27.6626 (mfDCA)
  • 263: 27.31 (mfDCA)
  • 9: 26.4013 (cMI)
  • 300: 23.2395 (mfDCA)
  • 3: 23.1959 (mfDCA)
  • 3: 23.1959 (mfDCA)
  • 166: 22.8794 (mfDCA)
  • 166: 22.8794 (mfDCA)
  • 5: 20.0005 (cMI)
  • 201: 18.6094 (mfDCA)
  • 10: 17.4958 (cMI)
  • 14: 17.3247 (cMI)
  • 249: 14.8015 (mfDCA)
  • 12: 13.6194 (cMI)
MT-ND1 · c.2T>C (p.Met1Thr) protein-coding
Genome location
D-loop · dloop · 16024–16569D-loop · dloop · 1–576MT-TF · tRNA · 577–647MT-RNR1 · rRNA · 648–1601MT-TV · tRNA · 1602–1670MT-RNR2 · rRNA · 1671–3229MT-TL1 · tRNA · 3230–3304MT-ND1 · protein · 3307–4262MT-TI · tRNA · 4263–4331MT-TQ · tRNA · 4329–4400MT-TM · tRNA · 4402–4469MT-ND2 · protein · 4470–5511MT-TW · tRNA · 5512–5579MT-TA · tRNA · 5587–5655MT-TN · tRNA · 5657–5729MT-TC · tRNA · 5761–5826MT-TY · tRNA · 5826–5891MT-CO1 · protein · 5904–7445MT-TS1 · tRNA · 7446–7514MT-TD · tRNA · 7518–7585MT-CO2 · protein · 7586–8269MT-TK · tRNA · 8295–8364MT-ATP8 · protein · 8366–8572MT-ATP6 · protein · 8527–9207MT-CO3 · protein · 9207–9990MT-TG · tRNA · 9991–10058MT-ND3 · protein · 10059–10404MT-TR · tRNA · 10405–10469MT-ND4L · protein · 10470–10766MT-ND4 · protein · 10760–12137MT-TH · tRNA · 12138–12206MT-TS2 · tRNA · 12207–12265MT-TL2 · tRNA · 12266–12336MT-ND5 · protein · 12337–14148MT-ND6 · protein · 14149–14673MT-TE · tRNA · 14674–14742MT-CYB · protein · 14747–15887MT-TT · tRNA · 15888–15953MT-TP · tRNA · 15956–16023MT-ND1m.3308T>C
MT-ND1 · protein-coding
protein tRNA rRNA D-loop
3D structure: where is this variant?
highlighted: residue 1 of MT-ND1 · drag to rotate, scroll to zoom.
General information
Variant ID MITHRIL.9923
MitImpact ID MI.10758
Chromosome chrM
Position 3308
Alleles (Ref/Alt) T/C
Molecule type protein-coding
Gene MT-ND1
Gene description mitochondrially encoded NADH:ubiquinone oxidoreductase core subunit 1
Gene (start-end) 3307-4262
Position within gene 2
Strand +
HGVS NC_012920.1:m.3308T>C
Functional effect Start lost
Respiratory chain complex I
External identifiers
Ensembl gene ENSG00000198888
Ensembl transcript ENST00000361390
Ensembl protein ENSP00000354687
UniProt NU1M_HUMAN (P03886)
NCBI gene 4535
NCBI protein YP_003024026.1
OMIM 516000
HGNC HGNC:7455
dbSNP rs28358582
MITOMAP allele 3308T>C
Phylogenetic conservation
PhyloP (100V) 4.722
PhastCons (100V) 1
PhyloP (470-way) 0.458
PhastCons (470-way) 0.156
Amino-acid change
Codon substitution ATA/ACA
Reference AA M
Alternate AA T
AA position 1
Pathogenicity predictors
PolyPhen-2 Probably damaging
SIFT Deleterious
SIFT4G Deleterious
PROVEAN Neutral
MutationTaster Polymorphism
EFIN (SwissProt) Deleterious
EFIN (HumDiv) Deleterious
LIST-S2 Deleterious
ESM1b Neutral
SNPDryad Neutral
Mitoclass1 Neutral
CADD Neutral
VEST Neutral
MLC Deleterious
Meta-predictors
APOGEE1 Deleterious
APOGEE2 VUS-
CAROL Deleterious
Condel Neutral
COVEC WMV Deleterious
MToolBox Deleterious
DEOGEN2 Neutral
Cancer-specific predictors
CHASM Neutral
Clinical significance & phenotype
MITOMAP status Reported---possibly-synergistic|-hg-L1b-and-A2i-marker
MITOMAP clinical info MELAS-/-DEAF-enhancer-/-hypertension-/-LVNC-/-putative-LHON
MITOMAP disease (hom/het) -/+
MITOMAP disease GenBank freq 0.7455
MITOMAP disease GenBank seqs 410 (0)
ClinVar significance Benign/Likely benign
ClinVar disease
  • not specified
  • Leigh syndrome
  • SUDDEN INFANT DEATH SYNDROME
+1 more
  • Carcinoma of colon
ClinVar ID (allele ID) 9728 (24767)
ClinVar disease DB
+1 more
ClinVar submitter IDs
Allele frequencies
MITOMAP known variant True
MITOMAP GenBank freq (seqs) 0.7455 (498)
HelixMTdb hom AF (AC) 0.0057 (1126)
HelixMTdb het AF (AC) 0.0001 (26)
HelixMTdb mean (max) ARF 0.5015 (0.9464)
gnomAD hom AF (AC) 0.0285 (1609)
gnomAD het AF (AC) 0.0001 (5)
gnomAD AN 56409
gnomAD filter PASS
ToMMo 61KJPN AF (AC) 0.0006 (36)
ToMMo 61KJPN AN 61424
Residue interaction & stability
ΔΔG intra MT-ND1:M1T:I166M:0.187932:0.694942:-0.594445;MT-ND1:M1T:I166V:1.32052:0.694942:0.715933;MT-ND1:M1T:I166N:2.41197:0.694942:1.63769;MT-ND1:M1T:I166L:0.258827:0.694942:-0.420996;MT-ND1:M1T:I166S:1.69698:0.694942:0.970766;MT-ND1:M1T:I166F:2.94585:0.694942:1.16217;MT-ND1:M1T:A201T:3.85398:0.694942:3.20878;MT-ND1:M1T:A201P:0.18953:0.694942:-0.598678;MT-ND1:M1T:A201D:5.17909:0.694942:4.42968;MT-ND1:M1T:A201V:2.8054:0.694942:2.44106;MT-ND1:M1T:A201S:1.10206:0.694942:0.373424;MT-ND1:M1T:A249G:0.98068:0.694942:0.24999;MT-ND1:M1T:A249T:1.26798:0.694942:0.585672;MT-ND1:M1T:A249P:-0.208264:0.694942:-0.969457;MT-ND1:M1T:A249V:1.08682:0.694942:0.387706;MT-ND1:M1T:A249E:0.873783:0.694942:-0.081467;MT-ND1:M1T:P2S:0.753602:0.694942:0.119094;MT-ND1:M1T:P2H:1.52221:0.694942:0.926272;MT-ND1:M1T:P2L:0.762225:0.694942:0.109703;MT-ND1:M1T:P2T:0.776941:0.694942:0.178692;MT-ND1:M1T:P2A:1.08902:0.694942:0.449523;MT-ND1:M1T:M3L:1.08406:0.694942:0.320405;MT-ND1:M1T:M3V:1.35668:0.694942:0.898191;MT-ND1:M1T:M3T:1.84671:0.694942:1.3373;MT-ND1:M1T:M3K:1.31349:0.694942:0.647219;MT-ND1:M1T:M3I:0.853114:0.694942:0.24161;MT-ND1:M1T:A201G:1.47336:0.694942:0.725;MT-ND1:M1T:I166T:1.3438:0.694942:0.604375;MT-ND1:M1T:A249S:1.10331:0.694942:0.416877;MT-ND1:M1T:P2R:1.29039:0.694942:0.63914
ΔΔG intra-interface MT-ND1:NDUFA1:5lc5:H:a:M1T:A249E:1.65741:1.65165:0.01115;MT-ND1:NDUFA1:5lc5:H:a:M1T:A249G:1.57875:1.65165:-0.0572;MT-ND1:NDUFA1:5lc5:H:a:M1T:A249P:1.68909:1.65165:-0.00503;MT-ND1:NDUFA1:5lc5:H:a:M1T:A249S:1.53585:1.65165:-0.08213;MT-ND1:NDUFA1:5lc5:H:a:M1T:A249T:1.84086:1.65165:0.19588;MT-ND1:NDUFA1:5lc5:H:a:M1T:A249V:1.83738:1.65165:0.16957;MT-ND1:NDUFA1:5ldw:H:a:M1T:A249E:0.94848:0.89206:0.02682;MT-ND1:NDUFA1:5ldw:H:a:M1T:A249G:1.44197:0.89206:0.38432;MT-ND1:NDUFA1:5ldw:H:a:M1T:A249P:0.96906:0.89206:-0.0544;MT-ND1:NDUFA1:5ldw:H:a:M1T:A249S:0.46892:0.89206:-0.69158;MT-ND1:NDUFA1:5ldw:H:a:M1T:A249T:1.11346:0.89206:0.24228;MT-ND1:NDUFA1:5ldw:H:a:M1T:A249V:1.04144:0.89206:0.18985
Intra-protein co-variation
1 ↔ 4: 32.9132 (mfDCA)1 ↔ 175: 30.1899 (mfDCA)1 ↔ 2: 29.9569 (mfDCA)1 ↔ 239: 27.6626 (mfDCA)1 ↔ 239: 27.6626 (mfDCA)1 ↔ 263: 27.31 (mfDCA)1 ↔ 9: 26.4013 (cMI)1 ↔ 300: 23.2395 (mfDCA)1 ↔ 3: 23.1959 (mfDCA)1 ↔ 3: 23.1959 (mfDCA)1 ↔ 166: 22.8794 (mfDCA)1 ↔ 166: 22.8794 (mfDCA)1 ↔ 5: 20.0005 (cMI)1 ↔ 201: 18.6094 (mfDCA)1 ↔ 10: 17.4958 (cMI)1 ↔ 14: 17.3247 (cMI)1 ↔ 249: 14.8015 (mfDCA)1 ↔ 12: 13.6194 (cMI)1 ↔ 4: 32.9132 (mfDCA)432.91321 ↔ 175: 30.1899 (mfDCA)17530.18991 ↔ 2: 29.9569 (mfDCA)229.95691 ↔ 239: 27.6626 (mfDCA)23927.66261 ↔ 239: 27.6626 (mfDCA)23927.66261 ↔ 263: 27.31 (mfDCA)26327.311 ↔ 9: 26.4013 (cMI)926.40131 ↔ 300: 23.2395 (mfDCA)30023.23951 ↔ 3: 23.1959 (mfDCA)323.19591 ↔ 3: 23.1959 (mfDCA)323.19591 ↔ 166: 22.8794 (mfDCA)16622.87941 ↔ 166: 22.8794 (mfDCA)16622.87941 ↔ 5: 20.0005 (cMI)520.00051 ↔ 201: 18.6094 (mfDCA)20118.60941 ↔ 10: 17.4958 (cMI)1017.49581 ↔ 14: 17.3247 (cMI)1417.32471 ↔ 249: 14.8015 (mfDCA)24914.80151 ↔ 12: 13.6194 (cMI)1213.619411

Same protein (MT-ND1); edge ∝ covariation score.

Show all 18 as text
  • 4: 32.9132 (mfDCA)
  • 175: 30.1899 (mfDCA)
  • 2: 29.9569 (mfDCA)
  • 239: 27.6626 (mfDCA)
  • 239: 27.6626 (mfDCA)
  • 263: 27.31 (mfDCA)
  • 9: 26.4013 (cMI)
  • 300: 23.2395 (mfDCA)
  • 3: 23.1959 (mfDCA)
  • 3: 23.1959 (mfDCA)
  • 166: 22.8794 (mfDCA)
  • 166: 22.8794 (mfDCA)
  • 5: 20.0005 (cMI)
  • 201: 18.6094 (mfDCA)
  • 10: 17.4958 (cMI)
  • 14: 17.3247 (cMI)
  • 249: 14.8015 (mfDCA)
  • 12: 13.6194 (cMI)